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Rutgers comprehensive program of animal care includes protocol review, a duly-constituted animal care committee, occupational health and laboratory safety, and full-time veterinary care. Our animal care facilities are USDA-registered and accredited by AAALACi, an association widely recognized for its standards of excellence in laboratory animal care and has an Animal Welfare Assurance with the US Public Health Service (PHS), a requirement for conducting any PHS/NIH-funded animal work. Animal Care works closely with the Institutional Animal Care and Use Committees (IACUC) to provide the highest quality animal care and veterinary oversight of our research animals in support of this commitment to humane animal research.

Confocal microscopy permits one to optically section a fluorescent sample (such as a cell that has been stained with contrasting fluorescent dyes) with superior resolution by using a pinhole to reject light that originates outside of the chosen area. By collecting a series of such images through the depth of a sample, the user may assemble a highly accurate three-dimensional reconstruction of the entire sample.

The SP8 TCS confocal microscope allows users to make proper and detailed observations of fast biological processes. The benefits of super-resolution, high-speed imaging, and the capability to image multiple fluorescent markers simultaneously. With the use of LIGHTNING, users can trace the dynamics of multiple molecules, even those expressed at low levels, simultaneously over long recording times in living specimens. Quantitative imaging methods such as Fluorescence Recovery After Photobleaching (FRAP) are available. The facility maintains workstations with software packages for image processing.

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At the Genomics Center, we specialize in Next-Generation Sequencing. We are a one-stop service provider for all the aspects of NGS, from library preparation to data analysis. We routinely sequence DNA and RNA samples of all kinds and from various sources, using established as well as custom protocols.

The purpose of the Genome Editing shared resource is to provide a centralized laboratory for the generation and preservation of mouse research models and creation of custom genome edited cell lines. In addition to its service functions, the shared resource plays an important intellectual role in the development and pursuit of mouse-oriented research projects and the application of genome editing throughout the Rutgers Cancer Institute’s consortium. The shared resource also engages in the development of new approaches and methodologies in genome editing to better serve its users.

Managed by Animal Care, the Gnotobiotic Core at Rutgers provides investigators with the ability to work with germ-free and SPF mice. Currently, the core maintains a germ-free colony with C57BL/6 GF mice. Our germ-free mice are completely free of exogenous, bacterial, fungal and viral microorganisms. To ensure they remain free of all exogenous microbes, our germ-free mice are housed in isolator cages and are routinely monitored. These mice are ideal for the study of the microbiome. The Gnotobiotic Core also provides investigators with a laboratory that contains a biosafety cabinet and incubator for experimental needs.

The High Field NMR facility provides access to state-of-the art NMR spectroscopy. This includes access to five high field NMR spectrometers, modern high-end solution and solids probes, pulse sequences, sample preparation strategies, and experimental know how, to perform the most up-to-date NMR experiments. The facility is capable of solution and solid-state biomolecular NMR, materials and polymer characterization, and pharmaceutical investigations. The facility provides access and training on the NMR instruments and varying degrees of staff support for novice through experienced users.

The imaging core facility offers a broad range of instruments to meet microscopy needs: from bright field and true color imaging, to epifluoresence, laser confocal, super-resolution, multispectral, and live imaging. The facility also offers image analysis software for use, including deconvolution, 3D-reconstruction, and advanced segmentation analysis.

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The Immune Monitoring & Advanced Genomics Shared Resource provides standardized, robust analytical assays that query the status of the immune system. The combination of Immune Monitoring and Advanced Genomics offers a single pipeline for extensive correlative analysis. The state-of-the-art facility provides consultation, sample processing, advanced flow cytometry, cytokine analysis using the Luminex-200 platform, bulk gene expression analysis using the NanoString platform, and single-cell RNA sequencing using libraries created with 10X genomics technology.

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The mission of In Vivo Research Services (IVRS) is to provide centralized high quality, cost-effective research services to both academic and industry clients. Rutgers has a wealth of experience, capabilities and models that are routinely used to answer critical in vivo research questions. IVRS provides a comprehensive program of animal care including consultation, experimental design, protocol preparation, a duly constituted animal care and use committee, occupational health and laboratory safety, BSL3 in vivo biohazard research, and full-time veterinary care. Rutgers offers competitive fee-for-service pricing, confidentiality, accuracy, and rapid service.

The IFH Data Core serves as a centralized shared survey, data, and research resource facility for its users. The core enables access to a variety of data sets and resources. The IFHSDC provides analytical, survey, and general support services to investigators through experienced and specialized research personnel with the expertise to design and conduct a scientifically rigorous and efficient survey and data analysis.