Chlamydiae are common and important human pathogens. This HealthAdvance grant will apply a novel technology to develop a safe and effective life attenuated Chlamydia vaccine. Our vaccines will drastically reduce health and socioeconomic burdens of chlamydial diseases in women and men.
A team of Rutgers researchers merged their ideas and technology with the support of research mentors to get the needed funds for developing a novel device capable of detecting the presence of viruses like SARS-CoV-2 in one’s breath.
The long-term goal of this project is to develop a vaccine using centanamycin for DNA viruses where no drug or vaccine is available. Our study offers an attractive opportunity to develop chemically-attenuated live viruses as vaccines for the prevention and treatment of DNA viral infections.
One of the most critical hurdles to developing CRISPR-based therapies for genetic disorders is the lack of effective delivery systems. To this end, this project aims todevelop a next-generation CRISPR delivery solution for fast and effective genome editing that supports the need for the CRISPR-based drug development market.
The proposed technology will repair peripheral nerve injuries (PNI) by utilizing a biodegradable biopolymer scaffold enclosing a hydrogel-peptide matrix-based 3Dsystem combined with cultured autologous human cells to augment nerve growth once implanted.
Tuberculosis is characterized by 10 million cases and 1.5 million deaths per year. New drugs are needed to reduce treatment duration and to treat drug-resistant infections. We propose a solution based on our preclinical drug lead (JSF-3285) that inhibits the essential ß-ketoacyl synthase and exhibits promising efficacy and safety profiles.
We have identified potent small molecule MIF inhibitors that reduce inflammation-associated cytokines in blood cell and mouse assays, and simultaneously exhibit favorable drug likeness properties including oral availability. They hold promise for the treatment of human inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn’s disease.