HealthAdvance Fund

Molecular structure

The team is developing a novel, first-in-class, orally-available drugs efficacious against tuberculosis and non-tuberculous mycobacterial lung infections. The candidates, RifaAAPs, are active against drug-susceptible, drug-resistant, multi-drug-resistant, and extensively-drug-resistant strains, have lower resistance emergence than current drugs, have higher sterilizing activity than current drugs, and have additive activity in combination with current drugs.