A team of Rutgers researchers merged their ideas and technology with the support of research mentors to get the needed funds for developing a novel device capable of detecting the presence of viruses like SARS-CoV-2 in one’s breath.
The proposed technology will repair peripheral nerve injuries (PNI) by utilizing a biodegradable biopolymer scaffold enclosing a hydrogel-peptide matrix-based 3Dsystem combined with cultured autologous human cells to augment nerve growth once implanted.
We have engineered a bispecific killer cell engager (BiKE) that binds to CD16a receptors on the surface of natural killer (NK) cells with high affinity and specificity.
Tuberculosis is characterized by 10 million cases and 1.5 million deaths per year. New drugs are needed to reduce treatment duration and to treat drug-resistant infections. We propose a solution based on our preclinical drug lead (JSF-3285) that inhibits the essential ß-ketoacyl synthase and exhibits promising efficacy and safety profiles.
We have identified potent small molecule MIF inhibitors that reduce inflammation-associated cytokines in blood cell and mouse assays, and simultaneously exhibit favorable drug likeness properties including oral availability. They hold promise for the treatment of human inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn’s disease.
This project aims to advance nanoparticle-based contrast agents for pre-clinical imaging of tumors in small animals. The project focuses on (i) scaling up contrast agent synthesis, (ii) assembly of a prototype imaging system, and (iii) proof of concept studies to monitor tumor growth and response to therapy.
The prevention of microbial adhesion and biofilm formation on medical device/tissue interfaces is an urgent and unmet need. Thi surface functionalization technology, which is specifically effective in preventing biofilm formation on medical devices, such as implants, aims to address this critical healthcare problem.