Many bacterial diseases are becoming more deadly as bacteria develop resistance to treatment with antibiotics. The proposed work describes an innovative path to identifying novel antibiotics.
HealthAdvance Fund®
A team of Rutgers researchers merged their ideas and technology with the support of research mentors to get the needed funds for developing a novel device capable of detecting the presence of viruses like SARS-CoV-2 in one’s breath.
Quantum Click is a software capable of formulating new drug candidates by screening billions of compounds virtually. Due to the exceptionally high accuracy, Quantum Click provides robust predictions of drug candidate-protein target interactions.
The long-term goal of this project is to develop a vaccine using centanamycin for DNA viruses where no drug or vaccine is available. Our study offers an attractive opportunity to develop chemically-attenuated live viruses as vaccines for the prevention and treatment of DNA viral infections.
One of the most critical hurdles to developing CRISPR-based therapies for genetic disorders is the lack of effective delivery systems. To this end, this project aims todevelop a next-generation CRISPR delivery solution for fast and effective genome editing that supports the need for the CRISPR-based drug development market.
The proposed technology will repair peripheral nerve injuries (PNI) by utilizing a biodegradable biopolymer scaffold enclosing a hydrogel-peptide matrix-based 3Dsystem combined with cultured autologous human cells to augment nerve growth once implanted.
We have engineered a bispecific killer cell engager (BiKE) that binds to CD16a receptors on the surface of natural killer (NK) cells with high affinity and specificity.