Small Molecule MIF Inhibitors for the Treatment of Inflammatory Bowel Disease
Inventor(s): Spencer Knapp and Achyutharao Sidduri
Awarded: July 2021
The currently approved medications for IBD treatment, a multi-billion-dollar market, include anti-inflammatories such as corticosteroids, and immune system suppressors, including injectable anti-TNF antibodies such as Humira. These medications suffer from side effects, high cost, and unreliable efficacy. There is a pressing need for safe, effective, oral small molecules that operate by orthogonal mechanisms. Our macrophage migration inhibitory factor (MIF) inhibitors (MW ~ 400) reduce inflammation-associated cytokines in blood cell and mouse assays. They simultaneously exhibit promising drug likeness properties including oral availability, permeability, metabolic stability, and colon localization, and are stable, low cost, and non-toxic. New MIF inhibitors may have additional potential applications in treating cytokine storm afflictions, multiple sclerosis, rheumatoid arthritis, and cancer.
- Ulcerative colitis
- Crohn’s disease
- Cytokine storm