Development of Biodegradable Nanoscaffolds for in vivo Drug Delivery and Stem Cell Differentiation
Inventor (s): Ki-Bum Lee; Letao Yang
Date Awarded: February 2019
Summary:
Stem cell therapy that can secrete trophic factors and differentiate into specific functional cells holds great potential for treating diseases and tissue injuries. However, low survival rate and incomplete differentiation of stem cells in vivo remain a critical barrier for stem cell therapy before its full potential can be realized. To address the challenges above, the Rutgers team will develop biodegradable hybrid inorganic nanoscaffold-based stem cell therapies. This project will focus on comprehensive evaluation studies of the biocompatibility, degradation and therapeutic effects of this technology. Ultimately, the success of the current TechAdvance project will pave the road for a biodegradable hybrid nanoscaffold system towards FDA approval and provide a new treatment for patients suffering from incurable tissue injuries and diseases.
Market Applications:
- Stem cell therapy
- Regenerative medicine
- Central nervous system injuries/diseases
- Drug delivery
- Research tools
- MRI imaging
