This proposal seeks to characterize and optimize inhibitors of Gα12 to serve as novel bronchodilators in the treatment of the common and devastating diseases of asthma and chronic obstructive lung disease.
TechXpress
Development of mouse model for SARS-CoV2 infection, that is amenable to easy manipulation and testing is essential for developing new therapeutics to counter the virus.
The overall goal of the present study is the discovery of potent and orally bioavailable mGluR5 agonists that elicit repair following a demyelination lesion.
To build drug-likeness properties into candidate molecules at an early stage, we will establish the efficacy of orally available small molecule macrophage migration inhibitory factor (MIF) inhibitors against IBDs in animal models. Should a suitable candidate(s) emerge from these studies, structural corrections for solubility, permeability, toxicity, and metabolic vulnerability are expected to be minimized, leading to a faster and more direct drug approval process.
The current work targets a surprisingly overlooked but promising mechanism for the treatment of hyperuricemia in gout - the inhibition of guanine metabolism.
A method and system that enables three-dimensional (3D) co-culture of different types of cells. The membrane based stackable constructs are designed to culture cells which act as cell scaffolds, while allowing oxygen diffusion and exchange of chemical signaling between layers.