Getting Started

The Molecular Design and Synthesis Core focuses on the design and synthesis of small molecule probes to investigate new biology. In collaboration with other biomedical scientists, these probes are used to interrogate biological pathways to create preliminary data for grant applications as well as to design molecules for diagnostic and therapeutic use. The core has established research collaborations with biotech companies and Rutgers investigators.

Services

Our current capabilities include:

• Molecular Design through interpretation of SAR by experienced medicinal chemists
• Computer Assisted Drug Discovery and virtual screening
• Synthesis of a wide variety of chemotypes (heterocycles/chiral synthesis) as crystalline solids or lyophilized salts, 98% purity
• Instrumentation including microwave reactors, LC/MS, analytical and preparative HPLC, NMR and X-ray structure determination

Our core staff also have experience in cGMP Active Pharmaceutical Ingredients process development and management of API production using an outsourcing approach for Phase 1 to Phase 2 production.